Lizelle was born in Pretoria and completed her primary and secondary school education at Hoërkool Warmbad. She has completed the following degrees: BA (UP), BBibl (UNISA), BA Hons Information and Knowledge Management (RAU) and a MPhil Information and Knowledge Strategy – Cum Laude (US). Her career started at the Department of Finance in 1983. She then joined Unisa and thereafter worked for the Department of Health in the tertiary education arena and college affiliated with RAU.
Since 1999 she has gained extensive knowledge in the Banking Industry, more specifically at Nedcor Technology and Operations until 2004 and then at FNB in several divisions including Branch and Commercial Banking.